Observations Concerning the Pathogenesis and the Epidemiology of Mouse Poliomyelitis *
نویسنده
چکیده
Since the beginning of 1940 a strain of albino mice has been bred in the Department of Hygiene and Bacteriology mainly for the purpose of studying mouse poliomyelitis. The descent of this strain is not definitely known, but it is probably a mixed breed of Swiss mice obtained from Denmark. It has later been crossbred with ordinary grey-coated wild mice (Mus musculus), the albinos of the F2 generation being selected for further breeding. The yield has averaged 6000 animals a year. During three and one-half years of dbservation two isolated cases of spontaneous mouse poliomyelitis have occurred. In addition, two accumulations of cases of the type of small epizootic outbreaks have been observed, one comprising 4 cases, the other 5 cases. Only young mice, 4 to 7 weeks old, have been attacked. As these occurrences might throw some light on the pathogenesis of the disease a description is given. The first isolated case appeared in May, 1940. Then nothing remarkable was observed until the following year, when, in July 1941, a number of young guinea-pigs were bought and housed in the same stable room as the stock of mice. After 2 weeks some of the guinea-pigs were showing symptoms of disease and in the course of about 2 months all of them died. The nature of the disease was not immediately recognized. As convulsions were a constant feature of the terminal stage the central nervous system was carefully examined for lesions, but with negative results. Cultures from blood and spleen gave, as a rule, no significant growth. It was observed, however, that the lymph nodes, especially the mesenteric glands, were frequently involved, being enlarged and with signs of hyperemia. In cultures from mesenteric glands Salmonella enteritidis (ratin) was constantly recovered, usually in pure culture.
منابع مشابه
The Surveillance System of Poliomyelitis/Acute Flaccid Paralysis in the Islamic Republic of Iran: History, Structures and Achievements
Background and Objectives: : According to the global strategy for polio eradication, targeted surveillance of the disease is one of the main tasks of the health system. The purpose of this study was to review the status and surveillance of poliomyelitis/acute flaccid paralysis (AFP) in Iran. Methods: The present study was a review on the processes, structures and achievements of the poliomy...
متن کاملMolecules and Mental Health
written with such clarity that readers who are not familiar with the field should have little or no difficulty understanding the material presented. Of particular current interest are the final three papers which deal with immunization against poliomyelitis. Dr. Albert Sabin presents a clear picture of present concepts of the pathogenesis of poliomyelitis (documented by careful investigation) w...
متن کاملPoliomyelitis Vaccine
The Epidemiology of poliomgelitis has been investigated in our country Pasteur Institute; the incidence of Poliomgelitis, after the age of 4 years i's rare, in Iran. Passive antibody of maternal origin do not interfere with production of active antibody after immunization. Inactivated Polio Vaccine (salk) has been effective in reducing the incidence of poliomgelitis by approximately 90 per ...
متن کاملObservations on the Incidence, Epidemiology, Control and Economic Importance of Gastro-Intestinal Parasites of Sheep and Goats in Iran
متن کامل
Galantamine Effect on Tularemia Pathogenesis in a BALB/c Mouse Model
Background: Galantamine is a drug used for the treatment of Alzheimer’s disease and some other cognitive disorders. It is an inhibitor of acetylcholinesterase however, interaction with nicotinic acetylcholine receptors has also been reported. Owing to the significant role of cholinergic anti-inflammatory pathways in neuro-immunomodulation, we decided to examine the effect of galantamine on tula...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 16 شماره
صفحات -
تاریخ انتشار 1944